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Genetic variation in HLA plays an important role in the pathogenesis of dermatomyositis (DM). The aim of this study was to investigate the association of HLA class II with DM in China. Two hundred and twenty‐four DM patients and 300 healthy controls were randomly enrolled at China‐Japan Friendship Hospital. High‐resolution typing of HLA‐DRB1 alleles was performed by sequencing based typing. The HLA‐DQA1...
Genetic studies in complex diseases have been highly successful, but have also been largely one‐dimensional: predominantly focusing on the genetic contribution to disease susceptibility. While this is undoubtedly important—indeed it is a pre‐requisite for understanding the mechanisms underlying disease development—there are many other important aspects of disease biology that have received comparatively...
HLA‐A*31:01 and HLA‐B*15:02 have been widely reported to confer genetic susceptibility to carbamazepine (CBZ)‐induced severe cutaneous adverse reactions (SCARs). Accordingly, the screening for these alleles has been highly recommended to prevent SCAR prior to introducing CBZ therapy. Although a number of methods are available for screening of HLA‐A*31:01 or HLA‐B*15:02 alleles separately, developing...
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free‐ranging animal populations strongly rely on natural resistance mechanisms, innate immunity‐related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next...
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